Table 2.

Regression models IV7 and PRS.

Variables	Impulsivity			Venturesomeness			Empathy
	Standard coefficient	T	Sig.	Standard coefficient	T	Sig.	Standard coefficient	T	Sig.
	β			β			β
Larger sample with covariate PRS, n = 903
Constant		14.178	<0.001		21.323	<0.001		13.582	<0.001
Sex	0.072	2.081	0.038	−0.293	−9.387	<0.001	0.342	10.305	<0.001
Age	−0.112	−3.118	0.002	−0.189	−5.857	<0.001	0.083	2.430	0.015
Depr	0.003	0.075	0.941	−0.053	−1.687	0.092	0.043	1.290	0.197
AnxDis	0.007	0.190	0.849	−0.140	−4.460	<0.001	−0.004	−0.106	0.915
SUDAlc	0.086	2.259	0.024	0.022	0.638	0.524	−0.003	−0.069	0.945
SUDCan	0.085	1.994	0.047	0.135	3.514	<0.001	0.055	1.356	0.175
SUDSed	0.007	0.207	0.836	0.041	1.266	0.206	0.003	0.073	0.942
SUDSti	0.032	0.708	0.479	−0.010	−0.260	0.795	0.065	1.511	0.131
SUDOpi	0.071	1.856	0.064	0.035	1.027	0.305	0.012	0.327	0.744
SUDCoc	0.020	0.467	0.640	0.050	1.297	0.195	−0.110	−2.698	0.007
SUDHal	0.016	0.378	0.705	0.011	0.290	0.772	−0.013	−0.303	0.762
Smaller sample with covariate PRS, n = 435
Constant		5.518	<0.001		7.976	<0.001		4.213	<0.001
Sex	0.188	3.805	<0.001	−0.242	−5.302	<0.001	0.361	7.728	<0.001
Age	−0.108	−2.142	0.033	−0.208	−4.501	<0.001	0.091	1.928	0.055
PRS	0.045	0.935	0.351	0.016	0.373	0.709	−0.024	−0.531	0.596
Depr	−0.016	−0.329	0.743	−0.086	−1.901	0.058	0.074	1.611	0.108
AnxDis	0.039	0.796	0.427	−0.164	−3.642	<0.001	0.023	0.491	0.624
SUDAlc	0.143	2.582	0.010	−0.006	−0.125	0.900	−0.048	−0.928	0.354
SUDCan	−0.028	−0.491	0.624	0.143	2.666	0.008	−0.020	−0.366	0.715
SUDSed	0.008	0.152	0.879	0.051	1.065	0.287	0.051	1.024	0.307
SUDSti	0.070	1.153	0.250	−0.011	−0.196	0.845	0.140	2.441	0.015
SUDOpi	0.048	0.932	0.352	0.041	0.877	0.381	0.042	0.858	0.391
SUDCoc	−0.069	−1.119	0.264	0.059	1.039	0.299	−0.106	−1.813	0.071
SUDHal	0.147	2.377	0.018	0.017	0.295	0.768	−0.026	−0.439	0.661

Table 2 shows the adjusted β values. T effect-sizes and p-values for the linear regression models with clinical comorbidities as covariates. SUD, substance use disorder; AnxDis, anxiety disorder; Depr, major depression; Alc, alcohol; Can, cannabis; Sed, sedatives; Opi, opioids; Coc, cocaine; Hal, hallucinogens; PRS, polygenic risk score.