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. 2020 Dec 14;11:591400. doi: 10.3389/fphar.2020.591400

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Copyright © 2020 Wang, Muhetaer, Zhang, Yang, Wang, Zhang, Wang, Zhang, Wang, Zheng, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SA suppresses migration and invasion in metastatic cells. (A) Representative phase-contrast images for wound healing assays. Left: quantification of migration distances; right: quantification of migration healing areas. (B) Representative images (left) and quantification (right) of decreased cell number in transwell chambers with or without SA (0–200 μg/ml). (C) Western blotting analysis of E-cad, N-cad and vimentin as well as gelatin zymography detection of MMP-2, and MMP-9 after the indicated SA treatment. All values represent the mean ± SD (n = 3, *p < 0.05, **p < 0.01).