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. 2020 Dec 14;11:591400. doi: 10.3389/fphar.2020.591400

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Copyright © 2020 Wang, Muhetaer, Zhang, Yang, Wang, Zhang, Wang, Zhang, Wang, Zheng, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SA suppresses breast cancer growth and metastasis in vivo and ex vivo. (A) Tumor volume, (B) body weight, (C) tumor-bioluminescence imaging, and (D) pulmonary metastatic nodules in nude mice bearing MDA-MB-231 cells with or without SA administration (n = 6, *p < 0.05, **p < 0.01). (E) The tumor foci in the control and SA-treated zebrafishes. Red fluorescence represented Dil-stained MDA-MB-231 cells, and yellow arrow labeled the position of disseminated tumor. (F) The effects of SA on autophagic flux was measured by LC3-GFP-mRFP reporter and the autophagy-associated indexes, LC3-II and p62, by western blotting analysis. Scale bar: 50 μM. (G) H&E staining and IHC detection of Ki-67, Cav-1, Hif-1α, vimentin, and E-cad expressions for each indicated group (n = 3, *p < 0.05, **p < 0.01).