Table 2.
Comparison of the characteristics between SD and DF or progression
| Patients | SD (n = 144) | DF or progression (n = 103) | p value |
|---|---|---|---|
| Age, yearsa | 54.3±7.0 | 54.3±6.8 | 0.976 |
| Male | 120 (83.3) | 91 (88.3) | 0.361 |
| Etiology of liver disease | |||
| Hepatitis B | 124 (86.1) | 90 (87.4) | 0.941 |
| Hepatitis C | 10 (6.9) | 8 (7.8) | |
| Alcohol | 4 (2.8) | 2 (1.9) | |
| Others | 6 (4.2) | 3 (2.9) | |
| Child-Pugh classification | |||
| Class A | 80 (55.5) | 35 (34.0) | 0.002 |
| Class B | 40 (27.8) | 47 (45.6) | |
| Class C | 24 (16.7) | 21 (20.4) | |
| MELD scoreb | 9 (7–14) | 11 (8–16) | 0.013 |
| Last AFP before LT, ng/mLb | 3.9 (10.1–46.0) | 49.9 (9.5–554.0) | <0.001 |
| Tumor characteristics on pretransplant imaging | |||
| Diameter of the largest viable tumora | 1.1±1.2 | 3.6±1.7 | <0.001 |
| Viable tumor,a | 1.0±1.8 | 5.3±5.7 | <0.001 |
| PET | n = 129 | n = 94 | |
| Positivity | 50 (38.8) | 46 (48.9) | 0.135 |
| LT after treatment | |||
| Types of treatment | |||
| TACE alone | 102 (70.8) | 59 (57.3) | 0.004 |
| RFA alone | 0 (0) | 4 (3.9) | |
| Resection alone | 3 (2.1) | 0 (0) | |
| Radiation alone | 1 (0.7) | 0 (0) | |
| Combination | 38 (26.4) | 40 (38.8) | |
| Radiologic complete response after treatment | 63 (43.8) | 0 (0) | <0.001 |
| Tumor characteristics on pathology | n = 113 | n = 103 | |
| Edmondson grade | |||
| I or II | 49 (43.4) | 30 (29.1) | 0.034 |
| III or IV | 64 (56.6) | 73 (70.9) | |
| MVI | 14 (12.4) | 43 (41.7) | <0.001 |
| Satellite nodule | 5 (4.4) | 33 (32.0) | <0.001 |
| Interval from initial HCC diagnosis to LT, monthsb | 12 (4–26) | 19 (10–47) | <0.001 |
Unless otherwise indicated, data represent number of patients, with percentage in parentheses, and compared by using the χ2 test or Fisher's exact test. SD, successful downstaging; DF, downstaging failure; MELD, Model for End-Stage Liver Disease; AFP, alpha-fetoprotein; LT, liver transplantation; PET, positron emission tomography; TACE, transarterial chemoembolization; RFA, radiofrequency ablation; HCC, hepatocellular carcinoma; MVI, microvascular invasion.
Data are continuous variables, reported as means±standard deviations, and were compared by using the 2-sample t test.
Data are continuous variables, reported as median with interquartile range, and were compared by using the Mann-Whitney U test.