Table 3.

Cox proportional hazards analysis of RFS and OS with pretransplant variables

	RFS						OS
	univariate analysis			multivariate analysis			univariate analysis			multivariate analysis
	HR	95% CI	p value	HR	95% CI	p value	HR	95% CI	p value	HR	95% CI	p value
Age (per year)	0.99	0.96–1.01	0.333				1.02	0.99–1.04	0.228
Male [female]	1.81	1.07–3.09	0.028	1.28	0.75–2.21	0.368	1.02	0.65–1.58	0.949
Etiology of liver disease
Hepatitis B [nonhepatitis B]	1.99	1.05–3.78	0.035	1.62	0.85–3.09	0.142	1.18	0.74–1.89	0.488
Child-Pugh classification
Class B or C [class A]	0.98	0.72–1.35	0.914				1.43	1.01–2.02	0.044	1.04	0.68–1.59	0.874
MELD score	0.99	0.97–1.02	0.537				1.03	1.01–1.05	0.001	1.03	1.01–1.06	0.012
Last AFP before LT ≥70 ng/mL [<70]	3.62	2.65–4.95	<0.001	1.77	1.25–2.51	0.001	3.02	2.18–4.18	<0.001	1.72	1.19–2.49	0.004
Initial OPTN stage
Initial OPTN T3 [initial OPTN T1 or T2]	3.48	2.55–4.75	<0.001	1.13	0.76–1.69	0.542	2.62	1.90–3.62	<0.001	1.16	0.76–1.76	0.488
Pretransplant HCC status exceeding the Milan criteria
[within the Milan criteria]	8.69	6.35–11.90	<0.001	5.12	3.37–7.78	<0.001	5.09	3.67–7.05	<0.001	3.31	2.13–5.15	<0.001
PET positivity [negativity]	3.81	2.77–5.25	<0.001	2.57	1.84–3.59	<0.001	3.39	2.42–4.74	<0.001	2.57	1.80–3.67	<0.001
LDLT [DDLT]	1.07	0.58–1.97	0.838				0.75	0.43–1.29	0.745
Interval from initial HCC diagnosis to LT (per month)	1.00	0.99–1.01	0.203				1.00	0.99–1.01	0.452

The reference category for each categorical variable is in the square brackets. A Cox proportional hazards regression analysis for RFS and OS was used. RFS, recurrence-free survival; OS, overall survival; HR, hazard ratio; CI, confidence interval; MELD, Model for End-Stage Liver Disease; AFP, alpha-fetoprotein; LT, liver transplantation; OPTN, Organ Procurement and Transplantation Network; HCC, hepatocellular carcinoma; PET, positron emission tomography; LDLT, living donor liver transplantation; DDLT, deceased donor liver transplantation.