Fig. 3.

Overall survival of patients who developed distant metastases during follow-up. a Comparison to patients who did not develop distant metastases: group B1 (FU = Yes) versus group B2 (FU = No). Patients with baseline metastases were excluded. b Influence of new pulmonary metastases on survival. Analysis includes all patients without pulmonary metastases at baseline and compares those who developed pulmonary metastases during follow-up, FU(lung) = Yes, to those who did not, FU(lung) = No. c Influence of new bone metastases on survival. Analysis includes all patients without bone metastases at study inclusion and compares those who developed bone metastases during follow-up, FU(bone) = Yes, to those who did not, FU(bone) = No.