Fig. 1.

On the right-hand side, the hierarchy links meaningful aspects of health (MAHs) to concepts of interest (COIs) to outcomes and endpoints. On the left-hand side, critical patient input is highlighted. Defining MAH and COI should take precedence over technical aspects of defining outcomes and endpoints. For a given individual and condition, multiple MAHs can be relevant, equally multiple COIs can inform a given MAH. These relationships may change over time and across individuals. Reproduced with permission from [68].