Table 2.

Predictors of survival in the whole study population according to the Cox regression analysis (including treatment received)

Variable	Univariate analysis			Multivariable analysis
	HR	95% CI	p value	HR	95% CI	p value
Age, year	1.004	0.986–1.023	0.654
Male sex	0.738	0.511–1.065	0.105
Aetiology
Healthy liver	−	Reference	−
HBV infection	0.625	0.306–1.274	0.196
HCV infection	1.088	0.698–1.697	0.710
Non-viral liver disease	0.783	0.495–1.241	0.298
Cirrhosis	0.955	0.667–1.367	0.802
ECOGPS > 0	2.036	1.398–2.966	<0.001	1.137	0.731–1.769	0.568
Main tumour dimension, mm	1.009	1.005–1.014	<0.001	1.003	0.998–1.009	0.227
Multinodular disease	2.304	1.590–3.339	<0.001	1.832	1.203–2.789	0.005
N1	1.228	0.743–2.028	0.423
M1	3.839	2.195–6.714	<0.001	1.804	0.912–3.596	0.090
Tumour grading
G1	−	Reference	−	−	Reference	−
G2	1.446	0.965–2.166	0.074	1.456	0.943–2.249	0.090
G3	2.141	1.299–3.527	0.003	1.533	0.900–2.611	0.116
Treatment
Surgery	−	Reference	−	−	Reference	−
Locoregional procedures	2.005	1.231–3.265	0.005	2.201	1.322–3.665	0.002
Chemotherapy	6.062	3.710–9.904	<0.001	3.211	1.719–6.000	<0.001
BSC	16.585	7.696–35.742	<0.001	13.889	5.887–32.766	<0.001

ECOG PS, Eastern Cooperative Oncology Group Performance Status.