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Regulation of Q neuroblast divisions during L1 arrest. ins-3, ins-4, and presumably other agonistic ILPs secreted from chemosensory neurons and possibly other tissues in response to food activate IIS, leading to the activation of PP2A and the RAF-MEK-ERK MAP kinase cascade and Q neuroblast divisions (Zheng et al. 2018b). Factors required to arrest cell divisions are shown in red. See text for details.
