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. 2020 Nov 4;7(6):ENEURO.0293-20.2020. doi: 10.1523/ENEURO.0293-20.2020

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Copyright © 2020 Govindaiah et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 1. — Excitatory glutamatergic synaptic transmission in dLGN and SC. A, Whole-cell voltage-clamp recordings showing the excitatory postsynaptic activity evoked by repetitive electrical stimulation of the OT for dLGN (left) and SC (right) neuron. Repetitive stimulation at 20 Hz evoked a train of EPSCs that rapidly depressed with each successive pulse. B, Paired stimulation (ISI, 50 ms) also led to strong paired-pulse depression in which the amplitude of the second (EPSC₂) is greatly reduced compared with the initial one (EPSC₁). Responses were abolished (red traces) by the bath application of glutamate receptor antagonists (AMPA: DNQX 25 μm) and (NMDA: d-CPP 20 μm). All responses recorded at −70 mv.