Figure 4.

The effects of N and P/Q channel blockade on paired pulse depression in dLGN and SC neurons. A, B, Summary plots that depict PPRs for individual dLGN (A, n = 5) and SC (B, n = 6) neurons, along with the group mean ± SEM (large symbols). Also included (right y-axis) are paired differences for each neuron, along with error bars that reflect the 95CI. Dotted horizontal lines depict the group mean difference (effect size) during drug treatment (top) and the mean for predrug values. Selective blockade of P/Q for dLGN (*p = 0.0078) and N for SC (*p = 0.0027) led to an increase in PPRs, and thus a weakening in paired pulse depression. All responses recorded at −70 mv.