Figure 4.

Pharmacogenetic reduction of adult neurogenesis does not alter short-term social memory. A, Schematic of three-trial social memory test with a 30 min delay between trials. B, Both CD1 and GFAP-TK (TK) mice with VGCV treatment decrease their investigation times for a familiar mouse and increase their investigation times for a new novel mouse (novel 2). C, There was no change in difference scores (novel 1 minus familiar or familiar minus novel 2) between genotypes treated with VGCV; n = 20 for CD1 and n = 21 for TK. Bars represent mean ± SEM; *p < 0.05. For comparison of mice with 24 h delay and 30 min delay paradigms, see Extended Data Figure 4-1.