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. 2020 Dec 23;7(6):ENEURO.0202-20.2020. doi: 10.1523/ENEURO.0202-20.2020

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Copyright © 2020 Lyon et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 2. — Drd2^Pet1^-CKO mice are largely behaviorally normal. Drd2^Pet1^-CKO (blue symbols) mice show behaviors indistinguishable from controls (black symbols) in measures of locomotion: (A, B) open field test and (C) rotarod; measures of anxiety-like and depression-like behavior: (D) elevated plus maze, (E) tail suspension test, and (F) forced swim test; or learning and memory: (G) contextual fear conditioning and (H) water T maze; n = 15 control mice (8 males, 7 females) and 11 Drd2^Pet1^-CKO (6 males, 5 females), except for C where, n = 21 control mice (14 males, 7 females) and 18 Drd2^Pet1^-CKO (13 males, 5 females). Each symbol represents one animal, error bars represent SEM. No significant differences (p > 0.05) between Drd2^Pet1^-CKO and controls were observed. No sex-specific (male vs female) phenotypes observed. For assay details, see Materials and Methods; for statistical details, see Table 2.