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. 2020 Dec 23;7(6):ENEURO.0202-20.2020. doi: 10.1523/ENEURO.0202-20.2020

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Copyright © 2020 Lyon et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 3. — Drd2^Pet1^-CKO females, but not males, display attenuated acoustic startle responses (ASR). A, Schematic of ASR experimental design. After an initial 5-min acclimation, mice are exposed to 10 blocks of 11 trials of auditory stimuli ranging from 20 to 120 dB in quasi-randomized order with a 10- to 20-s intertrial interval (ITI). B, Schematic of ASR measurement apparatus, mouse is placed in a perforated holding chamber atop transducer platform adjacent to speaker (for detailed description, see Materials and Methods). C, F, Averaged ASR magnitudes (mean ± SEM) across increasing stimulus intensities in (C) male Drd2^Pet1^-CKO (blue, n = 13) and controls (black, n = 14), no significant difference, p = 0.7745, two-way ANOVA and (F) female Drd2^Pet1^-CKO (blue, n = 15) and controls (black, n = 16), Drd2^Pet1^-CKO females display significantly attenuated ASR, p = 0.0011, two-way ANOVA. D, G, Group averaged ASR for 10 trials at 110-dB stimulus in (D) males and (G) females, demonstrates no habituation to the startle stimulus; x-axis numbers refers to trial number out of 110 total trials. E, H, No significant differences in latency to startle are observed in (E) males, p = 0.1319, two-way ANOVA and (H) females, p = 0.5452, two-way ANOVA. I, J, No significant differences in prepulse inhibition of acoustic startle are observed in (I) males (n = 8 control, 6 Drd2^Pet1^-CKO), p = 0.4325, two-way ANOVA or (J) females (n = 7 control, 5 Drd2^Pet1^-CKO, p = 0.4380, two-way ANOVA).