Table 2.
Extracellular matrix (ECM)-related genes upregulated or downregulated in YkiS168A discs.
| ECM-Related Genes Altered in YkiS168A-Expressing Discs (Relative to Control) | |
| Gene | Annotated Function (FlyBase.org) |
| Upregulated | |
| dpy | ECM protein involved in cuticle attachment |
| mmy | Protein glycosylase involved in ECM and cuticle construction |
| wb | Laminin-α chain ECM protein; BM integrity and integrin signaling |
| serp | Secreted apical ECM protein involved in cuticle construction |
| trol | Perlecan ECM secreted heparan sulfate proteoglycan |
| verm | Chitin deacetylase involved in cuticle development |
| Timp | Inhibitor of matrix metalloproteinases, regulates ECM remodeling |
| by | Tensin, binds integrin/actin to regulate wing surface adhesion |
| mgl | Apical membrane protein, cuticle development |
| Ndg | Structural ECM protein, organizes BM assembly |
| Mmp1 | Matrix metalloproteinase, regulates ECM remodeling |
| mfas | Regulator of cell adhesion and hemocyte proliferation |
| sona | ADAM protease in ECM, positive regulator of tissue growth |
| mspo | Spondin family ECM glycoprotein |
| Crag | Rab exchange factor involved in BM protein secretion |
| scaf | Inactive serine protease, regulates Laminin localization in BM |
| Gasp | Regulator of cuticle biosynthesis |
| Cpr47Eb | Structural component of cuticle |
| if | Integrin α-subunit of receptor for ECM |
| Itgbn | Integrin β-subunit of receptor for ECM |
| Vinc | Vinculin; mechanotransducer in cell-matrix interactions |
| stck | Integrin adaptor protein, wing disc apposition |
| plx | RabGAP, regulates integrin-mediated adhesion |
| Pax | Paxillin; integrin adaptor |
| Itgbn | |
| Downregulated | |
| Dg | Non-integrin ECM-actin adapting receptor |
| dlp | Glypican ECM membrane heparan sulfate proteoglycan |
| Glt | Secreted component of BM |
| LanB2 | Laminin-B2; BM component interacts with ECM and integrins |
| Mmp2 | Metalloproteinase, regulates ECM remodeling |
| Mp | Collagen XV/XVIII member |
| Ppn | ADAM-like protein, regulates ECM construction |
| Pxn | Peroxidase, regulates BM assembly |
| scb | α-PS3 Integrin, ECM ligand function |
| SPARC | Collagen and ECM-binding protein; BM maturation |
| Tig | Integrin ligand component of ECM |
| Tsp | Integrin ligand component of ECM |
Notable ECM-related genes identified as statistically upregulated or downregulated in YkiS168A-expressing discs compared to Control discs.