Figure 1.

Overview of immunotherapy approaches in non-Hodgkin lymphomas. Legend: Simplified overview of basic principles of immunotherapy including monoclonal antibodies (A), bispecific antibodies (B), checkpoint inhibitors (PD-1, PD-L1) (C), activators of co-stimulatory molecules (4-1BB) (D), CARs (E), and immunomodulation (F). Abbreviations: bsAb = bispecific antibody; CAR = chimeric antigen receptor; FcγR = receptor for constant fragment (Fc) of immunoglobulin gamma; mAb = monoclonal antibody; MHC = major histocompatibility complex; NK = natural killer; PD-1 = programmed cell death 1; PD-L1 = PD-1 ligand 1; TCR = T-cell receptor; Tu = tumor.