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. 2020 Nov 26;12(12):3515. doi: 10.3390/cancers12123515

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Network analysis of multi-omics data by MetaCore network building tool. (A) Proteomics data were analyzed for direct interactions among both upregulated and downregulated seed nodes. (B) Targeted-mRNA data were analyzed for direct interactions among upregulated RNA seed nodes. (C) Probable signaling cascade to invoke the proinflammatory cytokine response. Network was derived from direct interaction between members with ≥3 connections of both datasets along with candidate cytokines. (D) Direct interactions among targets that were upregulated in poor responders.