Table 1.
Characteristics of rheumatoid arthritis patients with insufficient response versus sufficient response to MTX (combination) therapy.
| Insufficient Responders (DAS28-ESR > 3.2) N = 41 |
Sufficient Responders (DAS28-ESR ≤ 3.2) N = 41 |
p-Value | |
|---|---|---|---|
| Baseline DAS28, mean ± SD | 4.3 ± 1.3 | 5.6 ± 1.0 | <0.001 |
| Age, mean ± SD | 50.0 ± 11.9 | 52.6 ± 16.9 | 0.41 |
| Sex, Male, N (%) | 8 (20) | 15 (37) | 0.14 |
| BMI (kg/m2), mean ± SD | 28.1 ± 5.4 | 24.3 ± 4.1 # | <0.001 |
| RF positive, N (%) | 26 (63) | 33 (80) | 0.14 |
| ACPA positive, N (%) | 25 (61) | 31 (76) | 0.24 |
| Treatment | |||
| MTX + SSZ + HCQ + corticosteroids i.m. | 8 (20) | 15 (37) | 0.14 |
| MTX + SSZ + HCQ + corticosteroids per os | 11 (27) | 15 (37) | 0.48 |
| MTX + corticosteroids per os | 13 (32) | 7 (17) | 0.20 |
| MTX | 9 (22) | 4 (10) | 0.23 |
# BMI, N = 1 missing value, BMI = body mass index, MTX = methotrexate, SSZ = sulfasalazine, HCQ = hydroxychloroquine, i.m. = intramuscular. RF = rheumatoid factor, ACPA = anti-citrullinated protein antibody