Table 1.
Treatment protocols applied to hamster groups, protection percentage, infection, and kidney lesion rates.
| Group | Treatment | n | Survivors (Protection %) | Infection Rates a PCR Culture |
NI b | Kidney Lesions Rates | p-Value c | ||
|---|---|---|---|---|---|---|---|---|---|
| A | GspDLC + no adjuvant + challenge | 8 | 5 (65.5) | 8 | 3 | 0 | 4.875 | 0.0555 | NS d |
| B | GspDLC + IFA + challenge | 8 | 6 (75) | 5 | 4 | 3 | 5 | 0.0176 | |
| C | Bacterin + challenge | 8 | 8 (100) | 1 | 1 | 7 | 3.5 | 0.0002 | |
| D | IFA + challenge | 13 | 2 (15.3) | 13 | 8 | 0 | 7.75 | ND e | |
| E | Saline + challenge | 5 | 0 (0) | 5 | 5 | 0 | 8.4 | 1 | NS d |
aLeptospira infection was determined by PCR and culture. b NI, Not infected hamsters. c p-values are two-sided and were obtained through comparison with group D (Fisher’s exact test). d NS, Not significant at p > 0.05. e ND, Not determined.