Figure 3.

Generation of OPN fragments by thrombin cleavage. OPN can be post translationally modified by thrombin cleavage. Two conserved thrombin cleavage sites have been identified in human OPN. The major site, Site-1 cleavage, produces an N-terminal fragment containing the RGD domain OPN-N1, and a C-terminal fragment OPN-C1. The Site-2 cleavage exposes a cryptic site, the SVVYGLR domain located within the RGD domain. The Site-2 cleavage produces N-terminal fragment, OPN-N2 containing the SVVYGLR domain and C-terminal fragment, OPN-C2. The figure was created in Biorender.com.