. 2020 Jul 19;11(1):309–325.e3. doi: 10.1016/j.jcmgh.2020.07.006

Supplementary Table 1.

Pearson Correlation Analysis of Vitamin A With Various Parameters of NAFLD in Mice Fed High-Fat, High-Cholesterol Diet

	Retinol		Retinyl palmitate		Plasma retinol		Total cholesterol
	r	P	r	P	r	P	r	P
Retinol	1.000
Retinyl palmitate	–.5090^a	.0094^a	1.000
Plasma retinol	–.8336^a	.0001^a	.3138	.155	1.000
Total cholesterol	–.6705^a	.0002^a	.4537^b	.0227^b	.4132^b	.0447^b	1.000
Free cholesterol	–.6163^a	.0023^a	.2172	.3316	.3996	.0654	.8713^b	<.0001^b
Triglycerides	–.7264^a	<.0001^a	.4399^b	.0357^b	.3746	.0858	.8338^b	<.0001^b
Plasma total cholesterol	–.8558^a	<.0001^a	.3956	.0557	.7992^b	<.0001^b	.7002^b	<.0001^b
Plasma free cholesterol	–.6987^a	.0001^a	.3970	.0547	.7933^b	<.0001^b	.6201^b	.0007^b
Plasma insulin	–.4819^a	.0199^a	.1850	.3981	.3288	.1352	.4454^b	.0257^b
Ldlr	–.3034	.1404	–.0385	.8552	.3247	.1216	.0712	.724
Srb1	–.4420^a	.0269^a	.3330	.1038	.2512	.2364	.6968^b	<.0001^b
Cd36	–.7852^a	<.0001^a	.4761^b	.0161^b	.8182^b	<.0001	.5167^b	.0058^b
Scd1	–.8337^a	<.0001^a	.4571^b	.0216^b	.7339^b	<.0001^b	.6488^b	.0003^b
Fasn	–.6557^a	.0004^a	.2310	.2666	.5699^b	.0036^b	.3909^b	.0438^b
Acc1	–.6317^a	.0007^a	.2304	.2679	.5549^b	.0049^b	.4235^b	.0277^b
Tnfa	–.6956^a	.0001^a	.2370	.2541	.8304^b	.0001^b	.5063^b	.0071^b
Nos2	–.5468^a	.0057^a	.3073	.1441	.6059^b	.0022^b	.3951^b	.0457^b
Ccl2	–.6086^a	.0012^a	.2781	.1784	.7633^b	<.0001^b	.4329^b	.0241^b
Il1b	–.6533^a	.0004^a	.4088^b	.0425^b	.3854	.0629	.6062^b	.0008^b
Il6	–.3023	.1511	.3158	.1327	.0613	.7863	.4628^b	.0198^b
Co1a1	–.6398^a	.0006^a	.1263	.5473	.7626^b	<.0001^b	.4320^b	.0244^b
Acta2	–.6355^a	.0006^a	.1773	.3965	.6210^b	.0012^b	.5299^b	.0045^b
Tgfb	–.7158^a	<.0001^a	.2572	.2145	.7649^b	<.0001^b	.6454^b	.0003^b
Timp1	–.5585^a	.0037^a	.0657	.7552	.7044^b	.0001^b	.3541	.07

Pearson correlation analysis of hepatic vitamin A (retinol, retinyl palmitate) with circulatory vitamin A (plasma retinol) with various parameters of diet-induced NAFLD progression. A correlation was also calculated between tissue and circulatory vitamin A with hepatic gene expression of markers for the progression of NAFLD. D P ≤ .05 considered significant.

NAFLD, nonalcoholic fatty liver disease.

Significant inverse correlation.

Positive correlation.