Table 4. Summary Table of the Benchmark^a.

methodology	Prime	MM	MOE	MD	Moloc	conformator	ETKDG	MMFF94s	UFF	CCDC
RMSDheavy atoms (Å)	0.878	0.655	0.765	1.052	1.910	1.990	2.165	1.793	2.083	2.067
RMSDbackbone (Å)	0.396	0.383	0.417	0.562	0.652	0.801	0.743	0.668	0.766	0.476
number of conformations	972	300	76	1000	67	338	1000	998	535	8
TF	707	100	48	59	67	338	1000	998	535	8
span RoG (Å)	1.02	0.93	0.74	0.85	0.86	0.87	0.82	1.13	1.08	0.15
exhaustiveness	1.00	1.00	1.00	1.00	1.00	0.91	1.00	0.95	0.95	1.00
SE	0.76	0.33	0.63	0.06	1.00	0.66	1.00	0.95	0.95	0.75
speed	9.8 min	3.9 h	31.1 min	3.1 d	38.9 min	17.9 h	35.1 s	1.3 min	17.6 s	2.6 s

^aData are medians.