Fig. 2.

Heatmaps of 3D-CNN classifications compared to voxel-wise group difference maps between AD and CN participant groups. a Relevance heatmaps of 3D-CNN classification of AD and CN. The bright areas represent the regions that most contribute to the CN/AD classification in CNN. Selected regions with the highest contribution include the hippocampus, parahippocampal gyrus, thalamus, fusiform gyrus, and diencephalon. b SPM maps show similar regions of the brain as the 3D-CNN maps where tau deposition is significantly higher in the AD group compared to the CN group (Voxel-wise FWE-corrected p value < 0.05; minimum cluster size (k) = 50)