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. 2020 Dec 28;21(Suppl 21):534. doi: 10.1186/s12859-020-03885-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The general workflow of the Auto3DCryoMap. a The general workflow of the Auto3DCryoMap. The green part of the workflow shows the micrographs data preprocessing. The red part of the workflow shows the fully automated single-particle picking using DeepCryoPicker [10]. The blue part of the workflow shows the general flow of the good 2D single-particle selection using unsupervised learning and deep learning classification. The yellow part of the workflow shows the fully automated particle alignment. The gray part shows the 3D density map reconstruction using single-particle reconstruction. b Simulated top-view (circular) of the Apoferritin molecule shapes. c Apoferritin real-world top-view (circular) protein shape. d Simulated top-view (circular) of the KLH molecule shapes. e KLH real-world top-view (circular) protein shape. f Simulated side-view (square) KLH molecule shape. g KLH real-world side-view (circular) protein