Fig. 2.

Liver pathology in YFV-infected hFRG mice is similar to YFV-infected humans and macaques. Hematoxylin and eosin staining of FFPE liver sections collected from moribund naive and YFV-infected humans, macaques, wild-type mice, muFRG mice, and hFRG mice. Liver parenchyma is noticeably affected in humans, macaques, and hFRG mice, but not in wild-type or muFRG mice. Apoptotic cells, necrotic debris, and hypereosinophilic Councilman-Rocha-Lima bodies (arrowheads) are seen throughout the livers of affected hosts (Scale bars, 50 μm.)