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(a) Helical wheel diagram of parallel dimer CHD-4. (b)CD spectra of parallel and antiparallel CHD dimers in 50 mM aqueous KF, pH= 7.4. (c-d) Overlay of 20 lowest conformations derived from parallel dimer NMR analysis and the lowest energy structure. (e) Size exclusion chromatography to assess the oligomerization of the designed antiparallel (CHD3) and parallel (CHD4). Lysozyme, aprotinin, and vitamin B12 were used as molecular weight controls.
