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. 2020 Dec 24;7:1849543520983196. doi: 10.1177/1849543520983196

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Structure of the chimeric sgRNA, containing the targeting sequence of the crRNA and the hairpin loops of the tracrRNA. The repeat sequences of the crRNA and tracrRNA sequences are linked via a tetraloop to form one structure.