TABLE 1.

The pharmacokinetic parameters of IM and NDI following oral administration of 400 mg IM capsules or tablets according to one report.

Drug name	Formulation	t1/2 (h)	Cmax (ng/ml)	Tmax (h)	AUC24 (ng × h/mL)	CL/F (L/h)	References
IM	Tablet	15.9 ± 3.1	1,638 ± 604	2.5 (1.5–6.0)	19,019 ± 7,684	17.3 ± 5.1	Nikolova et al. (2004)
	Capsule	15.8 ± 2.9	1748 ± 702	2.5 (2.0–6.0)	19,959 ± 8,794	17.1 ± 5.8
NDI	Tablet	39.9 ± 10.1	204 ± 89	2.5 (1.0–8.0)	2,457 ± 947	—
	Capsule	37.4 ± 7.0	206 ± 80	2.5 (1.0–6.0)	2,563 ± 1,138	—

IM, imatinib mesylate; NDI, N-desmethyl imatinib.