Figure 1. Intra-amniotic administration of the alarmin HSP70.
(A) Pregnant C57BL/6 dams were intra-amniotically injected with heat shock protein 70 (HSP70) or saline (1X phosphate-buffered saline; PBS) on 16.5 days post coitum (dpc). (B) The rate of preterm birth of mice injected intra-amniotically with 200 ng/25 μL, 400 ng/25 μL, 500 ng/25 μL, 1 μg/25 μL, or saline. The black bars represent early preterm birth (<18.0 dpc) and the striped bars represent late preterm birth (18.0-18.5 dpc). N = 6-10 dams per group.