Skip to main content
. 2020 Dec 24;8(2):e933. doi: 10.1212/NXI.0000000000000933

Figure 4. Longitudinal Reduction of AHR Agonistic Activity Correlates With Increasing White Matter Atrophy and Lesion Load Volume in Individual Patients With RRMS.

Figure 4

(A) Analysis of AHR agonistic activity in 13 individual patients in serial measurements. Solid line shows correlation of sample drawing year with AHR agonistic activity. (B) Analysis of white matter volume in 13 individual patients in serial cerebral MRIs. Solid line shows correlation of drawing year with relative white matter volume in each individual patient. (C) Analysis of lesion load volume change in 13 individual patients in serial cerebral MRIs. Group 1 (7 patients) and group 2 (3 patients) consist of patients with a stable AHR activity course and were compared with group 3 consisting of 3 patients with a decreasing AHR activity course over the years. Lines represent mean and error bars SEM. **p < 0.01 by 1-way analysis of variance followed by the Tukey post hoc test. AHR = aryl hydrocarbon receptor; ns = not significant; RRMS = relapsing-remitting MS.