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Comparative FP-based assays showing that compound 79 potently inhibits the PBD of Plk1 but not Plk2 and Plk3 with an IC50 of 0.47 μM. Under the same experimental conditions, PLHSpT 6a shows an IC50 of 22 μM, whereas its control nonphosphorylated form, PLHST 6b, exhibits no detectable activity. Bars, mean ± standard deviation (s.d.).
