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Metabolic alkalosis: Mechanisms of generation
| Ingest and absorb or infuse NaHCO3 or NaHCO3 precursors (i.e., Na acetate, Na citrate, Na gluconate) |
| Distal renal tubule HCO3 generation through enhanced H+ secretion |
| Generous delivery of NaCl (or other Na salts such as Na2SO4 or Na penicillin) to distal tubules/collecting ducts, which are actively reabsorbing Na+ |
| K+ depletion (shifting H+ into cells) |
| Remove HCl from body (vomiting/nasogastric suction/chloride-rich diarrhea) |
