Table 5:
Hazard ratios (95% CIs) for incidence of stroke associated with progression of the combined microvascular brain disease measure from the 1st Brain MRI (1993-1995) to the 2nd brain MRI (2004-2006).
| HR | 95% CI | p | |
|---|---|---|---|
| Progression in the combined measure | |||
| No progression | 1 (Ref.) | - | - |
| Mild progression | 1.12 | 0.63-1.97 | 0.71 |
| Moderate progression | 3.03 | 1.31-7.00 | 0.01 |
| Age, per year | 1.08 | 1.02-1.15 | 0.01 |
| Female sex | 1.10 | 0.63-1.90 | 0.75 |
| African-American race | 1.46 | 0.81-2.63 | 0.21 |
| Education | |||
| Less than high school diploma | 1 (Ref.) | - | - |
| High school diploma | 0.94 | 0.49-1.83 | 0.87 |
| More than high school diploma | 0.76 | 0.39-1.46 | 0.40 |
| Time from 1st to 2nd MRI, per year | 0.88 | 0.65-1.21 | 0.44 |
| BMI, per 1 kg/m2 | 1.02 | 0.97-1.07 | 0.41 |
| Smoking | |||
| Never | 1 (Ref.) | - | - |
| Former | 1.47 | 0.85-2.56 | 0.17 |
| Current | 3.24 | 1.43-7.34 | 0.005 |
| Hypertension | 1.93 | 0.95-3.91 | 0.07 |
| Diabetes | 0.73 | 0.36-1.46 | 0.38 |
| CHD | 1.77 | 0.64-4.91 | 0.27 |
Progression in the combined WMH/lacune measure categories: no progression; mild progression (increase of ≥1 unit in WMH grade or new lacune), and moderate progression (increase of ≥1 unit in WMH grade and new lacune).
Grade of WMH categorized according to the Cardiovascular Health Study (CHS).