Figure 5.

(A) Typical domain organization of DDX helicases. The motifs are shown with colors according to their primary function (red, ATP binding and hydrolysis; yellow, coordination between NTP- and RNA-binding sites; blue, RNA binding). (B) Cartoon representation showing domain movements in DDX helicases upon RNA binding of the DEAD-box protein eIF4AIII without RNA (left) and in complex with RNA (right). An RNA fragment and AMPPNP are shown in stick representation in green and in cyan, respectively.