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DDX3X as a model for dsRNA unwinding mechanism by DDX helicases. (A) Domain organization and (B) cartoon representation of DDX3X in its proposed functional states, including the apo and pre-unwound states (pdb codes 5e7i and 6o5f, respectively), and its post-unwound state (pdb code: 2db3, ortholog from Drosophila melanogaster).
