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. 2020 Dec 24;13:13225–13236. doi: 10.2147/OTT.S278755

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© 2020 She et al.

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Schematic diagram of the regulatory network of the RBM38-p53 family. The p53 family consists of the p53, p63 and p73 genes. As a common target of the p53 family, RBM38 suppresses the activity of p53 and inhibits its expression, decreases the expression of p63 by reducing the stability of p63 transcripts, and increases the expression of p73 by improving the stability of p73 transcripts. A negative feedback loop between p53 and mdm2 is essential in tumor development: the activation of p53 induces mdm2 expression, while the binding of mdm2 to p53 inactivates p53, which inhibits p53 overexpression. RBM38 stabilizes the negative feedback loop of p53-mdm2 by inhibiting mdm2 and restoring p53 expression. In addition, RBM38 increases the expression of p21, another common target of the p53 family, by improving the stability of p21 transcripts and slowing their decay.