Table 2.

RBM38 and Tumors

Expression	Tumor	Function	References
Low	Breast cancer	RBM38 acts as a tumor suppressor by reducing c-Myc and enhancing PTEN expression. It participates in the tumorigenesis process by decreasing the ability of p53 to activate its target genes and regulate the expression of ER and PR.	[14,19,22]
Low	HCC	RBM38 restores the stability of the p53-mdm2 loop.	[16,64]
High	Lung cancer	RBM38 promotes lung cancer by inhibiting the translation of p53.	[65]
Low	Gastric cancer	The details need further research.	[23]
Low	AML	RBM38 stabilizes P21CIP1 to suppress AML.	[20]
High	Lymph cancer	RBM38 plays a role in lymphomagenesis by inactivating p53.	[24]
Low	Renal carcinoma	RBM38 binds to and stabilizes p21 mRNA, thereby inducing cell cycle arrest in the G1 phase.	[21]