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Model of SG assembly and disassembly. Upon RNA influx, key SG node and bridge proteins form a multi-interaction network, which causes LLPS and the assembly of SGs. Following stress removal, PTMs potentially lead to the loss of protein-protein, protein-RNA, and RNA-RNA interactions, leading to a decrease in valence and allowing subsequent SG disassembly. The schematic was created in ©BioRender (biorender.com); it is not time-resolved and does not resemble actual sizes and ratios.
