Table 6.
Ten most downregulated mRNAs in HUVECs upon pravastatin (10 µM) stimulation in comparison to controls
| Top 10 downregulated differentially expressed mRNAs in Statin‐treated versus Control endothelial cells | |||
|---|---|---|---|
| Nr | Gene symbol | Fold change | Adj. p‐value |
| 1 | ABI1 | 4.6038017 | .018848386 |
| 2 | SND1 | 4.4388801 | .004988181 |
| 3 | TMED2 | 4.135675 | .013520699 |
| 4 | RAB23 | 3.9035519 | .044063826 |
| 5 | SCAF8 | 3.7269421 | .017383289 |
| 6 | SNX10 | 3.566869 | .001821224 |
| 7 | EMD | 3.4986437 | .024932582 |
| 8 | SGK1 | 3.4659766 | .006466557 |
| 9 | B4GALT6 | 3.3686982 | .013007055 |
| 10 | PRIM2 | 3.3550803 | .035131682 |
Abbreviations: ABI1, Abl Interactor 1; Adj, Adjusted; B4GALT6, Udp‐Gal:Beta‐Glcnac Beta‐1,4‐Galactosyltransferase, Polypeptide 6; EMD, Emerin; PRIM2, Primase Polypeptide 2a; RAB23, Ras‐Associated Protein Rab23; SCAF8, Sr‐Related C‐Terminal Domain‐Associated Factor 8; SGK1, Serum/Glucocorticoid‐Regulated Kinase 1; SND1, Staphylococcal Nuclease Domain‐ And Tudor Domain‐Containing Protein 1; SNX10, Sorting Nexin 10; TMED2, Transmembrane emp24 Domain‐containing Protein 2