Table 8.
Results of bioinformatics analyses on downregulated pathways in HUVECs after pravastatin (10 µM) stimulation in comparison to controls
| Downregulated pathways in Statin‐treated versus Control endothelial cells | ||||
|---|---|---|---|---|
| Nr | Pathways | Count | Adj. p‐value | Genes |
| 1 | Pathways in cancer | 5 | .04629817 | CCDC6//JAK1//KIT//TRAF6//XIAP |
| 2 | Epstein‐Barr virus infection | 4 | .03368377 | EIF2AK4//JAK1//SND1//TRAF6 |
| 3 | Hematopoietic cell‐lineage | 3 | .01593718 | IL5//ITGA1//KIT |
| 4 | Neurotrophin signaling pathway | 3 | .03571419 | IRAK3//RPS6KA2//TRAF6 |
| 5 | Toxoplasmosis | 3 | .03571419 | JAK1//TRAF6//XIAP |
| 6 | Hepatitis C | 3 | .0461964 | EIF2AK4//JAK1//TRAF6 |
| 7 | Measles | 3 | .04705986 | EIF2AK4//JAK1//TRAF6 |
| 8 | Ubiquitin mediated proteolysis | 3 | .04969846 | TRAF6//UBE3A//XIAP |
| 9 | Autoimmune thyroid disease | 2 | .04216142 | IL5//TSHR |
| 10 | NOD‐like receptor signaling pathway | 2 | .04649291 | NOD2//TRAF6 |
Abbreviations Adj, Adjusted.