Level 3

Timing of treatment of patients with Muenke syndrome from the age of 6 to 9 months may have a favourable effect on the aesthetic outcome compared to an earlier intervention and is justified in view of the low prevalence of elevated ICP. Timing of treatment of patients with Apert, Crouzon or Saethre-Chotzen syndrome between the ages of 6 to 9 months may have a favourable effect on the aesthetic outcome compared to an earlier or later operation and seems appropriate given the high prevalence of elevated ICP. B De Jong, 2010; C Utria, 2015; Ridgway, 2011