Table 3. Associations between genetic polymorpisms, platelet reactivity and % inhibition.
| PRU* | % inhibition** | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | SNP | Alleles | NC median (IQR) | C median (IQR) | U statistics (z) | p-value | Effect size r | NC mean ± SD | C mean ± SD | Mean difference (95%CI) | p-value | Cohens d |
| CYP2C19*2 | rs4244285 | G>A | 74 (9–118) | 129 (83–162) | 1595 (3.756) | <0.01 | 0.37 | 65 ± 25.1 | 39 ± 23.4 | 25.7 (15.2;36.2) | <0.01 | 1.08 |
| CYP2C19*17 | rs21248560 | C>T | 104 (54–137) | 64 (9–126) | 856 (-1.779) | 0.08 | -0.18 | 52 ± 26.9 | 66 ± 27.2 | -13.5 (-25.0;-2.0) | 0.02 | 0.53 |
| CYP23A4*16 | rs2242480 | C>T | 103 (41–137) | 98 (60–116) | 872.5 (-0.703) | 0.48 | -0.07 | 57 ± 28.1 | 55 ± 25.3 | 1.55 (-10.9;13.9) | 0.81 | 0.08 |
| NR1I2 | rs13059232 | T>C | 89 (44–139) | 100 (47–130) | 748.5 (-0.066) | 0.95 | -0.01 | 58 ± 25.0 | 56 ± 28.2 | 1.86 (-12.4; 16.1) | 0.80 | 0.08 |
| P2Y12 | rs2046934 | C>T | 103 (53–135) | 87 (9–119) | 952 (-1.081) | 0.28 | -0.11 | 56 ± 26.6 | 57 ± 30.1 | -0.95 (-12.8; 10.9) | 0.85 | 0.04 |
| P2Y12 | rs9859552 | G>T | 83 (33–120) | 110 (68–139) | 1424.5 (1.777) | 0.08 | 0.18 | 59 ± 28.8 | 52 ± 24.8 | 6.81 (-4.6; 18.2) | 0.24 | 0.26 |
| P2RY12 | rs6785930 | G>A | 110 (53–142) | 89 (41–120) | 950 (-1.863) | 0.06 | -0.19 | 50 ± 27.0 | 59 ± 27.0 | -8.86 (-19.7; -2.0) | 0.11 | 0.33 |
SNP, single nucleotide polymorphism; NC, non-carriers; C, carriers; PRU, platelet reaction units; 95%CI, 95% confidence interval; IQR, Inter quartile range. Significant p-values in bold.
*Tested with Mann-Whitney U.
** Tested with independent samples T-test.