Table 2.
Summary of EBV-miRNAs expressed during gastric cancer pathogenesis.
| EBV related MIRNA | Summary of findings | References |
|---|---|---|
| miR-BART5 | upregulates p53 | (71, 72) |
| miR-BART3-3p | leads to the downregulation of p21 | (70) |
| miR-BART3-5p | targets DICE1 tumor suppressor | (73) |
| miR-BART9 | inhibits E-cadherin to induce a mesenchymal-like phenotype | (74, 75) |
| miR-BART5-3p | inhibits p53 Expression, | (62) |
| miR-BART5-5p/BART7-3p/BART9-3p/BART14-3p | regulates ATM activity in response to DNA damage | (63) |
| miR-BART1 | activates PTEN-dependent pathways including PI3K-Akt, FAK-p130 (Cas),, and Shc-MAPK/ERK1/2 signaling | (64) |
| miR-BART7-3p | targets human major tumor suppressor gene PTEN, regulates PI3K/Akt/GSK-3 β signal transduction | (65, 77, 83) |
| miR-BART10-3p | promotes Cell Proliferation and Migration by Targeting DKK1. | (66) |
| miR-BART10-3p/BART22 | activates the canonical Wnt signaling pathway. | (69) |
| miR-BART11 | promotes inflammation-induced carcinogenesis by targeting FOXP1. | (67, 68) |
| miR-BART9/BART11/BART12 | downregulate Bim expression | (76) |
| miR-BART4-5p | regulates Bid Expression | (77) |
| miR-BART20-5p | targets BAD | (78) |
| miR-BART16 | abrogates the production of IFN-stimulated genes | (79) |
| miR-BART22 | regulates LMP2A expression | (80) |
| miR-BART17-5 | targets Kruppel-Like Factor 2 | (81, 82) |
| miR-BART15-3p | targets the anti-apoptotic TAX1BP1 targets NLRP3 inflammasome |
(84) (85, 86) |