Figure 2.

Therapeutic Strategies Targeting Tumor-Associated Macrophages in the Pediatric Sarcoma Microenvironment. Therapy modalities include increasing phagocytosis of TAMs, inhibiting tumor metastases, inhibiting efferocytosis, checkpoint blockade, altering macrophage polarization through targeting immunosuppressive cytokines, metabolite depletion and blocking angiogenesis. TAM, tumor-associated macrophage; SIRPα, signal-regulatory protein alpha; MMP, matrix metalloprotease; PS, phosphatidylserine; TIM-4, T Cell Immunoglobulin And Mucin Domain Containing 4; MERTK, Mer receptor tyrosine kinase; PROS1, protein S; GAS6, growth arrest-specific 6; CTLA-4, cytotoxic T-lymphocyte-associated protein 4; PD-1, programmed cell death protein 1; PD-L1, programmed death ligand 1; mAB, monoclonal antibody; IL-10, interleukin 10; TGF-β, transforming growth factor beta; ARG1, arginase 1; VEG-F, vascular endothelial growth factor; CXCL8, C-X-C motif chemokine ligand 8; CCL2, C-C motif chemokine ligand 2. Image created with biorender.com