Table 3.

Uni- and multi-variate analyses of risk factors for LTP in HCCs treated by RFA.

	Univariate analysis			Multivariate analysis
Risk factors	HR	95%CI	P value	HR	95%CI	P value
Age (y)	0.988	0.950, 1.028	.560
Sex (male)	1.996	0.812, 4.908	.132
Tumor margin (ill-define)	2.251	0.968, 5.234	.060
Location
left lobe	0.996	0.119, 8.361	.997
right lobe	1.100	0.144, 8.422	.927
bilobar∗	1
Tumor size (≤3 cm)	0.240	0.519, 3.114	.600
Child-Pugh Class (B)	1.351	0.576, 3.168	.488
Presence of liver cirrhosis	0.544	0.235, 1.261	.156
Pretreatment laboratory markers
Albumin < 1.0mg/dL	1.165	0.475, 2.860	.739
AFP > 100 ng/mL	6.722	2.563, 15.600	<.001	1.558	0.433, 5.610	.497
ALT < 50 U/L	1.259	0.543, 2.921	.591
AST < 40 U/L	1.401	0.588, 3.343	.447
GGT > 60 U/L	1.018	0.415, 2.499	.969
Tumor number
1∗	1
2–3	4.698	1.961, 11.257	.001	1.847	0.703, 4.850	.213
Rim enhancement [present]	3.795	1.618, 8.902	.002	2.689	1.026, 7.049	.044
Presence of peritumoral enhancement [present]	1.059	0.357, 3.138	.918
Signal in T2-weighted images
hyperintense∗	1
isointense	3.330	0.429, 25.829	.250
hypointense	1.564	0.573, 4.273	.383
Signal on arterial phase
hyperintense∗	1
isointense	1.978	0.262, 14.921	.508
hypointense	1.294	0.434, 3.854	.644
Signal on portal phase
hyperintense∗	1
isointense	0.403	0.086, 1.702	.203
hypointense	0.372	0.086, 1.884	.248
Signal on delay phase
hyperintense	1
isointense	0.581	0.075, 4.481	.602
hypointense	0.607	0.075, 4.898	.604
ADC (×10−3mm2/s)	0.066	0.017, 0.256	<.001†	0.136	0.020, 0.899	.038