Table 3.
EAR for out‐of‐field organs (per 10,000 PY at the age of 70 yr following exposure at the age of 30 and 50 yr) for WBRT for right and left breasts, and WBRT plus RNRT for right and left breasts, as calculated using dose–response models.
| Site | Age at exposure | |||||||
|---|---|---|---|---|---|---|---|---|
| 30 | 50 | |||||||
| Left side irradiation | Right side irradiation | Left side irradiation | Right side irradiation | |||||
| WBRT | WBRT plus RNRT | WBRT | WBRT plus RNRT | WBRT | WBRT plus RNRT | WBRT | WBRT plus RNRT | |
| Ipsilateral lung | 14.0 | 20.5 | 11.6 | 17.6 | 14.6 | 21.3 | 12.1 | 18.3 |
| (9.51; 18.7) | (14.0; 27.4) | (7.89; 15.5) | (11.9; 23.4) | (8.58; 22.4) | (12.6; 32.8) | (7.12; 18.6) | (10.8; 28.1) | |
| \Stomach | 4.73 | 13.2 | 0.810 | 2.45 | 4.58 | 12.8 | 0.785 | 2.38 |
| (3.04; 6.97) | (8.46; 19.4) | (0.520; 1.19) | (1.58; 3.62) | (2.09; 7.96) | (5.83; 22.2) | (0.358; 1.36) | (1.08; 4.13) | |
| Thyroid | 0.141 | 5.50 | 0.121 | 1.38 | 0.0469 | 1.83 | 0.0405 | 0.460 |
| (0.0586; 0.258) | (2.29; 10.1) | (0.0506; 0.223) | (0.575; 2.53) | (0.00; 0.152) | (0.00; 5.96) | (0.00; 0.132) | (0; 1.50) | |
| Contralateral breast | 2.55 | 3.94 | 2.08 | 4.93 | 1.02 | 1.58 | 0.838 | 1.98 |
| (1.88; 3.32) | (2.91; 5.14) | (1.54; 2.72) | (3.64; 6.42) | (0.582; 1.63) | (0.899; 2.53) | (0.476; 1.34) | (1.12; 3.16) | |
| Large intestine | 0.424 | 2.81 | 0.147 | 0.492 | 0.0847 | 0.562 | 0.0293 | 0.0983 |
| (0.233; 0.636) | (1.55; 4.22) | (0.0807; 0.22) | (0.27; 0.737) | (0.0159; 0.207) | (0.105; 1.37) | (0.0055; 0.0715) | (0.0184; 0.240) | |
| Contralateral lung | 0.954 | 1.94 | 0.665 | 2.26 | 0.992 | 2.02 | 0.692 | 2.35 |
| (0.649; 1.27) | (1.32; 2.58) | (0.452; 0.887) | (1.53; 3.01) | (0.585; 1.53) | (1.19; 3.10) | (0.408; 1.06) | (1.38; 3.61) | |
| Esophagus | 0.116 | 1.52 | 0.0912 | 0.741 | ||||
| (0.0361; 0.221) | (0.47; 2.87) | (0.0283; 0.173) | (0.23; 1.41) | |||||
| Liver | 0.560 | 1.15 | 1.88 | 1.45 | 0.339 | 0.696 | 1.14 | 0.879 |
| (0.00; 0.938) | (0.00; 1.93) | (0.00; 3.15) | (0.00; 2.43) | (0.0652; 0.834) | (0.134; 1.71) | (0.219; 2.80) | (0.169; 2.16) | |
| Tongue | 0.0415 | 0.341 | 0.0340 | 0.178 | ||||
| (0.0148; 0.0889) | (0.122; 0.731) | (0.0121; 0.0729) | (0.0637; 0.382) | |||||
| Skin | 0.419 | 0.119 | 0.370 | 0.664 | 0.436 | 0.123 | 0.385 | 0.690 |
| (0.0359; 1.32) | (0.0102; 0.373) | (0.0317; 1.16) | (0.0569; 2.09) | (0.00; 0.347) | (0.00; 0.0983) | (0.00; 0.307) | (0.00; 0.550) | |
| Pancreas | 0.0676 | 0.111 | 0.0298 | 0.0944 | ||||
| (0.00; 0.221) | (0.00; 0.362) | (0.00; 0.0971) | (0.00; 0.308) | |||||
| Pituitary | 0.0132 | 0.0502 | 0.0099 | 0.051 | ||||
| (0.0044; 0.0246) | (0.0167; 0.0934) | (0.0033; 0.0184) | (0.017; 0.0948) | |||||
| Cerebellum | 0.0090 | 0.0394 | 0.0074 | 0.0574 | ||||
| (0.0030; 0.0167) | (0.0131; 0.0735) | (0.0025; 0.0138) | (0.0191; 0.107) | |||||
| Hypothalamus | 0.0096 | 0.0376 | 0.0065 | 0.0424 | ||||
| (0.0032; 0.0178) | (0.0125; 0.07) | (0.0022; 0.012) | (0.0141; 0.079) | |||||
| Thalamus | 0.0069 | 0.0272 | 0.0057 | 0.0343 | ||||
| (0.0023; 0.0129) | (0.0091; 0.0506) | (0.0019; 0.0105) | (0.0114; 0.0638) | |||||
| Gray matter | 0.0067 | 0.0259 | 0.0058 | 0.0333 | ||||
| (0.0022; 0.0125) | (0.0086; 0.0482) | (0.0019; 0.0108) | (0.0111; 0.062) | |||||
| White matter | 0.0067 | 0.0256 | 0.0057 | 0.033 | ||||
| (0.0022; 0.0124) | (0.0085; 0.0476) | (0.0019; 0.0106) | (0.011; 0.0613) | |||||
| Bladder | 0.0073 | 0.0131 | 0.0051 | 0.0199 | 0.0048 | 0.0086 | 0.0034 | 0.0131 |
| (0.0025; 0.0123) | (0.0045; 0.0221) | (0.0018; 0.0087) | (0.0069; 0.0337) | (0.0011; 0.0102) | (0.0021; 0.0184) | (0.0008; 0.0072) | (0.0031; 0.0280) | |
| Lt kidney | 0.0058 | 0.0093 | 0.0024 | 0.0081 | ||||
| (0.00; 0.0319) | (0.00; 0.0513) | (0.00; 0.0133) | (0.00; 0.0445) | |||||
| Rt kidney | 0.0026 | 0.0043 | 0.0028 | 0.0098 | ||||
| (0.00; 0.0142) | (0.00; 0.0237) | (0.00; 0.0154) | (0.00; 0.0538) | |||||
| Ovary | 0.0016 | 0.0029 | 0.0011 | 0.0041 | ||||
| (0.0001; 0.0037) | (0.0001; 0.0067) | (0.0000; 0.0026) | (0.0002; 0.0096) | |||||
| Uterus | 0.0014 | 0.0025 | 0.0010 | 0.0039 | ||||
| (0.00; 0.0047) | (0.00; 0.0083) | (0.00; 0.0034) | (0.00; 0.0132) | |||||
| Gall bladder | 0.00 | 0.00 | 0.00 | 0.00 | ||||
| (0.00; 0.0362) | (0.00; 0.0608) | (0.00; 0.0427) | (0.00; 0.136) | |||||
The linear‐exponential dose–response model was used for organs exposed over 2 Gy. The linear dose–response model was used for other organs. EAR based on Japanese atomic bomb survivor data is not reported if no value is shown. Values in parentheses are 90% confidence intervals.