Table 2. Univariate and multivariate Cox regression analysis for prognostic factors of survival outcome (n = 51).
| Variable | No. | OS | PFS | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | ||||||
| HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | ||
| T4 disease | 0.977 | NA | 0.726 | NA | |||||
| Yes | 21 | 1.0 (0.5–1.9) | 1.1 (0.6–2.0) | ||||||
| No | 30 | Reference | Reference | ||||||
| N3 disease | 0.959 | NA | 0.091 | NA | |||||
| Yes | 25 | 1.0 (0.5–1.9) | 1.6 (0.9–2.9) | ||||||
| No | 26 | Reference | Reference | ||||||
| M1 disease | 0.025 | 0.166 | 0.174 | NA | |||||
| Yes | 39 | 2.7 (1.1–6.6) | 1.6 (0.8–3.4) | ||||||
| No | 12 | Reference | Reference | ||||||
| Mutation type | 0.261 | NA | 0.467 | NA | |||||
| Deletion 19 | 23 | 0.7 (0.4–1.3) | 0.8 (0.4–1.4) | ||||||
| Others | 28 | Reference | Reference | ||||||
| Pleural effusion | 0.037 | < 0.001 | 0.044 | 0.003 | |||||
| Presence | 20 | 2.0 (1.1–3.7) | 4.0 (1.9–8.5) | 1.8 (1.0–3.3) | 2.7 (1.4–5.2) | ||||
| Absence | 31 | Reference | Reference | Reference | Reference | ||||
| Lung metastasis | 0.938 | NA | 0.742 | NA | |||||
| Presence | 19 | 1.0 (0.5–1.9) | 1.1 (0.6–2.0) | ||||||
| Absence | 32 | Reference | Reference | ||||||
| Hepatic metastasis | 0.026 | 0.903 | 0.234 | NA | |||||
| Presence | 6 | 2.8 (1.1–6.9) | 1.7 (0.7–4.2) | ||||||
| Absence | 45 | Reference | Reference | ||||||
| Skeletal metastasis | 0.491 | NA | 0.267 | NA | |||||
| Presence | 14 | 1.3 (0.6–2.6) | 1.4 (0.8–2.7) | ||||||
| Absence | 37 | Reference | Reference | ||||||
| Brain metastasis | 0.806 | NA | 0.579 | NA | |||||
| Presence | 6 | 1.1 (0.4–3.2) | 1.3 (0.5–3.0) | ||||||
| Absence | 45 | Reference | Reference | ||||||
| SUVmax | 0.018 | 0.166 | 0.140 | NA | |||||
| > 6.75 | 13 | 2.7 (1.2–6.3) | 1.7 (0.8–3.2) | ||||||
| ≤ 6.75 | 38 | Reference | Reference | ||||||
| TLG | 0.002 | 0.739 | 0.074 | NA | |||||
| > 101 | 24 | 3.0 (1.5–5.9) | 1.7 (1.0–3.0) | ||||||
| ≤ 101 | 27 | Reference | Reference | ||||||
| SUV entropy | 0.002 | <0.001 | 0.018 | 0.001 | |||||
| > 5.36 | 27 | 2.9 (1.5–5.7) | 5.5 (2.5–12.2) | 2.0 (1.1–3.6) | 2.9 (1.5–5.5) | ||||
| ≤ 5.36 | 24 | Reference | Reference | Reference | Reference | ||||
| Sum entropy | 0.001 | 0.841 | 0.063 | 0.586 | |||||
| > 5.8 | 21 | 3.5 (1.7–7.2) | 1.7 (1.0–3.1) | ||||||
| ≤ 5.8 | 30 | Reference | Reference | ||||||
| SAE | 0.021 | 0.783 | 0.195 | NA | |||||
| ≤ 0.845 | 34 | 2.3 (1.1–4.5) | 1.5 (0.8–2.8) | ||||||
| > 0.845 | 17 | Reference | Reference | ||||||
HR: Hazard ratio, CI: Confidence interval, OS: Overall survival, PFS: Progression-free survival, TLG: Total lesion glycolysis, SAE: Small zone emphasis.