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. 2020 Dec 28;15(12):e0243818. doi: 10.1371/journal.pone.0243818

Table 4. Factors associated with the increase in albumin levels.

Adjusted OR Lower 95% CI Upper 95% CI P value
Albumin <3 mg/dl 3.94 3.14 4.95 <0.0001
Age ≥80 years 0.54 0.46 0.65 <0.0001
eGFR<30 mL/min/1.73m2 0.65 0.53 0.80 <0.0001
BMI<22 kg/m2 0.80 0.67 0.94 0.0093
Anemia 1.26 1.05 1.51 0.01
NYHA III/IV 0.76 0.60 0.96 0.02
DM 0.83 0.70 0.997 0.046
COLD 0.84 0.66 1.07 0.16
SBP<90 mmHg 1.42 0.85 2.36 0.17
History of stroke 1.12 0.90 1.39 0.30
HFrEF 0.92 0.76 1.10 0.36
AF 1.04 0.88 1.23 0.61
History of MI 1.02 0.84 1.24 0.81
BNP or NT-pro BNP above median* 1.01 0.86 1.20 0.82
History of HF hospitalization 1.01 0.85 1.21 0.84
Female 1.01 0.85 1.20 0.85

*BNP value above 715.9 ng/L or NT-pro-BNP> 5744.1 pg/L.

OR = odds ratio, CI = confidence interval, eGFR = estimated glomerular filtration rate; DM = diabetes mellitus; BMI = body mass index; HFrEF = HF with reduced EF (<40%); COLD = chronic obstructive lung disease, SBP = systolic blood pressure; AF = atrial fibrillation/flutter; ACS = acute coronary syndrome; NYHA = New York Heart Association.