Supplementary Table 1.

Summary of registry sites with methodological variations

Site identifier	Clinic name	Location	Indication for biopsy	mpMRI specifications	mpMRI targeting system	Blinded or unblinded MRI
A	Urología Clínica, Clínica IMQ Zorrotzaurre	Bilbao, Spain	Clinical variables, including MRI	b-value ≥1400 no ERC	Cognitive fusion (micro-US-guided)	Unblinded
B	Urology of Virginia, Eastern Virginia Medical School	Virginia Beach, U.S.	Clinical variables, including MRI	3T Toshiba Titan no ERC b-value 2000	Cognitive fusion (micro-US-guided)	Blinded
C	Instituto Clinico Humanitas	Rozzano, Italy	Suspicious mpMRI only	1.5T and 3T	Biojet robotic fusion	Blinded
D	Glickman Urological Institute, Cleveland Clinic	Cleveland, U.S.	Clinical variables, including MRI	3T Siemens Skyra no ERC	Uronav software fusion	Unblinded
E	Charité Universitätsmedizin	Berlin, Germany	Clinical variables, including MRI	3T with pelvic phased array coil no ERC	Hitachi software fusion	Unblinded
F	Groupe Urologie Saint-Augustin	Bordeaux, France	Clinical variables, including MRI	1.5T and 3T	Cognitive fusion (micro-US-guided)	Unblinded
G	Sunnybrook Hospital	Toronto, Canada	Clinical variables, including MRI	Siemens and Phillips 3T, no ERC	Cognitive fusion (micro-US-guided)	Unblinded
H	Polyclinique Reims-Bezannes	Bezannes, France	Clinical variables, including MRI	1.5T and 3T	Cognitive fusion (micro-US-guided)	Unblinded
I	Institut Mutualiste Montsouris	Paris, France	Clinical variables, including MRI	3T no ERC	Cognitive fusion (micro-US-guided)	Unblinded
J	Ordensklinikum	Linz, Austria	Clinical variables, including MRI	1.5T and 3T	FusionVu micro-USguided	Unblinded
K	Carolina Urologic Research Center	Myrtle Beach, U.S.	Clinical variables, including MRI	1.5T and 3T	Cognitive fusion (micro-US-guided)	Unblinded

MRI: magnetic resonance imaging; US: ultrasound.