Table 3.
Progression of AKI during the first 48 h of ICU admission based on KDIGO criteria for SCr or urine output alone
| AKI creatinine | AKI urine output | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| Variable | No progression (n = 337) | Progression (n = 24) | P-value | No progression (n = 248) | Progression (n = 32) | P-value |
| Age (years), mean ± SD | 60 ± 16 | 62 ± 13 | 0.59 | 60 ± 16 | 63 ± 15 | 0.35 |
| Sex, n (%) | 0.09 | 0.07 | ||||
| Male | 213 (63) | 11 (46) | 157 (63) | 15 (47) | ||
| Female | 124 (37) | 13 (54) | 91 (37) | 17 (53) | ||
| DM, n (%) | 0.42 | 0.24 | ||||
| No | 275 (82) | 18 (75) | 195 (79) | 28 (88) | ||
| Yes | 62 (18) | 6 (25) | 53 (21) | 4 (13) | ||
| APACHE, mean ± SD | 54 ± 28 | 85 ± 28 | <0.001 | 53 ± 26 | 75 ± 29 | <0.001 |
| Weight (kg), mean ± SD | 79.8 ± 16.4 | 78.1 ± 16.5 | 0.63 | 79.5 ± 16.3 | 76.6 ± 178 | 0.40 |
| BMI (kg/m2), mean ± SD | 26.3 ± 4.7 | 26.4 ± 4.6 | 0.88 | 26.1± 4.6 | 26 ± 5.6 | 0.87 |
| Creatinine at admission (µmol/L), median (IQR) | 71 (58–91) | 114 (92–141) | <0.001 | 70 (58–94) | 76 (56–127) | 0.4 |
| NGAL at admission (µmol/L), median (IQR) | 121 (82–194) | 266 (157–458) | <0.001 | 121 (85–214) | 170 (130–371) | 0.02 |
| Confirmed infection at admission, n (%) | 0.27 | 0.9 | ||||
| No | 315 (94) | 21 (88) | 231 (93) | 30 (94) | ||
| Yes | 22 (7) | 3 (13) | 17 (7) | 2 (6) | ||
| KDIGO stage admission, n (%) | <0.001 | 0.05 | ||||
| 0 | 284 (84) | 13 (54) | 208 (84) | 22 (69) | ||
| 1 | 20 (6) | 9 (38) | 17 (7) | 6 (19) | ||
| 2 | 17 (5) | 2 (8) | 13 (5) | 1 (3) | ||
| 3 | 16 (5) | 0 (0) | 10 (4) | 3 (9) | ||
| RRT during admission, n (%) | 11 (3.3) | 8 (33) | <0.001 | 11 (4) | 5 (16) | 0.01 |
| Admission type, n (%) | 0.03 | 0.01 | ||||
| Scheduled surgery | 175 (52) | 6 (25) | 129 (52) | 7 (22) | ||
| Unscheduled surgery | 44 (13) | 6 (25) | 35 (14) | 7 (22) | ||
| Medical | 118 (35) | 12 (50) | 84 (34) | 18 (56) | ||
| ICU survival, n (%) | 0.34 | 0.56 | ||||
| No | 35 (10) | 4 (17) | 23 (9) | 4 (13) | ||
| Yes | 302 (90) | 20 (83) | 225 (91) | 28 (88) | ||
| ICU LoS (calendar days), median (IQR) | 2 (2–4) | 7 (4–10) | 0.05 | 2 (2–5) | 7.5 (4–16) | <0.001 |
LoS: length of stay.